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This unloading of the heart reduces myocardial energy consumption and oxygen requirements and probably accounts for the effectiveness of isoptin sr hydrochloride in chronic stable effort angina.

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Treatment of chronic atrial fibrillationrate controlprevention of paroxysmal supraventricular tachycardia.

It is soluble in waterchloroform and methanolVerapamil HCI is not chemically related to other cardioactive drugs.

Inhalation AnestheticsAnimal experiments have shown that inhalation anesthetics depress cardiovascular activity by decreasing the inward movement of calcium ionsWhen used concomitantlyinhalation anesthetics and calcium antagonistssuch as verapamilshould each be titrated carefully to avoid excessive cardiovascular depression.

Overdose with verapamil may lead to pronounced hypotensionbradycardiaand conduction system abnormalitiese.gjunctional rhythm with AV dissociation and high degree AV blockincluding asystoleOther symptoms secondary to hypoperfusione.gmetabolic acidosishyperglycemiahyperkalemiarenal dysfunctionand convulsionsmay be evident.

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histopathological examination of infertile males revealed changes in the testes and epididymides at 200 mgkgday about 30 times the verapamil isoptin .

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